Epigenetic Programing of B-Cell Lymphoma by BCL6 and Its Genetic Deregulation

Epigenetic Programing of B-Cell Lymphoma by BCL6 and Its Genetic Deregulation

Blog Article

B cell lymphoma is a clinically heterogeneous and pathologically diverse group of diseases with a strong epigenetic component.The B cell lymphoma 6 Backpacks (BCL6) gene encodes a transcription factor that is critical for normal germinal center reaction B cell development by maintaining an epigenetic and transcriptional state that is permissive for cellular proliferation and DNA damage.The activity of BCL6 can be deregulated by a variety of mechanisms and contributes to the development of B-cell lymphoma.Here we review the direct and indirect mechanisms BCL6 dysregulation in B cell lymphoma, including transcriptional and post-translational regulation of BCL6 expression and activity, and the perturbation of BCL6-regulated epigenetic programs by cooperating chromatin modifying gene mutations.

We underscore the critical importance of BCL6 and its associated epigenetic programs Sinus Supplements in the development of B-cell lymphoma, and discuss avenues for the therapeutic targeting of BCL6 in this context.